Abstract: College students are the vital force during the implementation of innovation driven development strategy and promotion of public entrepreneurship and innovation, thus, how to enhance their innovative spirit and entrepreneurial ability is major issue for higher education now. This paper deeply studies their basic understanding about entrepreneurship through questionnaire survey, and their true need on related knowledge, and established the College Students' Entrepreneurship Education System based on demand orientation, which include four combinations such as management and technology, lesson and practice, college and society, tracking and feedback. Finally, the strategy of “promoting the employment and entrepreneurship through innovation” is carried out on the level of college.