Abstract: In the process from the human-led knowledge creation and development to the new era of knowledge production jointly created by artificial intelligence technology and human beings for thousands of years, intelligent machines have begun to erode the unique knowledge production rights of human beings and gradually expanded to other fields. The iterative development of artificial intelligence technology has forced people to become "vassals" of complex, pluralistic and efficient intelligent social systems, and the "loss of subject" of people is imminent. The crisis of human subjectivity in the era of artificial intelligence is manifested as: the reduction of human free will, the aggravation of human self-alienation tendency, and the disappearance of human privacy security. In this regard, taking the changes in self-consciousness, technical standards and governance systems as the starting point, three solutions are proposed: (1)Enhance self-consciousness and strengthen the construction of human subjectivity; (2)Standardize technical standards and grasp the development direction of artificial intelligence; (3)Improve the governance system and open up a new path of scientific supervision. By doing so, artificial intelligence technology will return to the correct development track and help realize the free and comprehensive development of human beings.