Abstract: The great rejuvenation of the Chinese nation has entered an irreversible historical process, which is a major judgment made by General Secretary Xi Jinping using the grand view of history during the centenary of the founding of the Party. This major judgment has a solid basis: the stronger leadership of the Communist Party of China is the political guarantee; the solid economic foundation is the material guarantee; the more perfect socialist system with Chinese characteristics is the institutional guarantee; and scientific thinking and advanced culture are important spirits strength. Firmly grasping the irreversible historical opportunity of the great rejuvenation of the Chinese nation, it is necessary to further promote "the Party's leadership over all work", exercise full and rigorous governance over the party, coordinate the overall strategy of the great rejuvenation of the Chinese nation and the "profound changes unseen in a century", satisfy the people's ever-growing needs for a better life, and adhere to and develop the Chinese-style modernization path.