Abstract: Chloride penetration and freeze-thaw cycles deterioration of concrete are two major durability challenges for road infrastructure. Based on the numerical simulation method, analyzing the processes of water migration, ion transport, and heat transfer in concrete under the coupling effect of multiple physical fields is beneficial for revealing the degradation laws of concrete. Exploring the diffusion process of chloride and the degradation mechanism of freeze-thaw cycles is of great significance for predicting the service life of concrete. In this paper, under the background of research on the durability of concrete resistance to chloride penetration and freeze-thaw, the theory of chloride diffusion and degradation mechanism of freeze-thaw cycles were expounded. The application of mesoscopic numerical simulation methods in the durability of concrete resistance to chloride penetration and freeze-thaw cycles was sorted out. Based on chloride adsorption effect, different conditions and convection effect, the recent work of mesoscopic numerical simulation research in terms of chloride ion transport behavior was summarized. The research progress of numerical simulation of concrete under freeze-thaw cycles was summarized by considering the meso-structure characteristics and multi-physical field coupling. The influence of air-entrained bubbles on the frost resistance of concrete was emphasized. The coupling mechanism of the freeze-thaw cycle and chloride penetration on concrete was analyzed. Based on the mesoscopic numerical simulation technology, the durability evaluation methods of concrete resistance to freeze-thaw and chloride penetration were reviewed, aiming to provide some reference for the life prediction and durability design of concrete structures.